Elthrocin Tablet Adverse Reactions

Erythromycin and its salts and esters are generally well-tolerated and serious adverse effects are rare. The most frequent side effects of erythromycin preparations are gastrointestinal, e.g. abdominal/stomach discomfort and cramp, nausea, vomiting and diarrhoea. Supra-infection with resistant organisms may occur and there has been a report of pseudomembranous colitis associated with erythromycin use.
Allergic reactions ranging from urticaria and mild skin eruptions to anaphylaxis have occurred. There have been isolated reports of reversible hearing loss occurring chiefly in patients with renal insufficiency and in patients receiving high doses of erythromycin.
There have been isolated reports of transient central nervous system side effects including confusion, hallucinations, seizures and vertigo; however, a cause and effect relationship has not been established. Occasional case reports of cardiac arrhythmias, e.g. ventricular tachycardia have been documented in patients receiving erythromycin therapy. There have been isolated reports of other cardiovascular symptoms, e.g. chest pain, dizziness and palpitations; however, a cause and effect relationship has not been established.
Incidence less frequent: Hepatotoxicity: Symptoms include malaise, nausea, vomiting, abdominal cramps, skin rash, and fever. Jaundice may or may not be present. Liver function tests often indicate cholestasis. Symptoms typically appear within a few days to 1 or 2 weeks after the start of continuous therapy, and are reversible when erythromycin is discontinued.
Incidence rare: Cardiac toxicity, especially QT prolongation and torsades de pointes (irregular or slow heart rate; recurrent fainting; sudden death); pancreatitis (severe abdominal pain, nausea and vomiting).